pharmacology MCQs – Page 2

Practise focused pharmacology questions with marked answers for exam preparation and subject revision.

pharmacology Mcqs
51. Which of the following drug induces parkinsonism ?
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A. Chlorpromazine

B. Chloroquine

C. Chlorpheniramine

D. Chlorhexidine

52. Atypical Antipsychotic are all except______________?
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A. Olanzepine

B. Thioridazone

C. Risperidone

D. Clozapine

53. Benzodiazepine antagonist is________________?
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A. Naltrexone

B. Furazolidone

C. Naloxone

D. Flumazenil
54. DOPA and 5-Hydroxytryptophan are clinically important because_____________?
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A. They act as neuromodulators

B. They cross blood Brain Barriers

C. They are acidic precursors of Brain amines

D. They are metabolites of various neurogenic amines

55. All of the following statements about pain are correct except_____________?
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A. NSAIDS benefit by preventing prostaglandin synthesis

B. Analgesia is associated with ? and k receptors

C. Naloxane is a non-competitive antagonist and irreversibly opposes the opioids

D. Dysphoria is associated with S receptors

56. Drug that does not cause sedation________________?
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A. Zopiclone

B. Diazepam

C. Buspirone

D. Nitrazepam

57. The anti-inflammatory analgesic drug the causes least gastrointestinal symptoms is______________?
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A. Indomethacin

B. Phenyl butazone

C. Aspirin

D. Paracetamol
58. All of the following decrease skeletal muscle tone by CNS effects except____________?
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A. Beclofen

B. Diazepam

C. Mephensin

D. D-tubocurarin
59. Phenytoin is associated with_____________?
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A. Alzhiemers disease

B. Cushings syndrome

C. Vitamin C deficiency

D. Folic acid deficiency
60. Phenothiazines are used to____________?
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A. Produce analgesia

B. Alter psychotic behaviour

C. Suppress coughing

D. Produce muscle relaxation

61. Aspirine is useful in all the following conditions EXCEPT_____________?
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A. Gout

B. Fever

C. Post myocardial infarction

D. Venous thrombosis

62. A paralyzing dose of succinylcholine initially elicits______________?
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A. Muscle fasciculation

B. CNS stimulation

C. CNS depression

D. Decreased salivation

63. Drug which is used to control status epilepticus is______________?
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A. Pheno barbital

B. Diazepam

C. Sodium nitroprusside

D. Glyceryl trinitrite

64. The beneficial effect of drug neostigmine in the treatment of Myasthenia gravis is due to the action____________?
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A. It produces more acetycholine receptors

B. It increases the action of cholinesterase

C. It is produces more acetylcholine

D. It inhibits the action of cholinesterase
65. In which of the following stage general anesthesia surgery is done_______________?
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A. Stage III plane 3

B. Stage I

C. Stage II

D. Stage III plane 2

66. Nitrates are not used in______________?
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A. Esophageal spasm

B. Cyanide poisoning

C. CCF

D. Renal colic
67. Which of the following histamine blockers has no effect on muscarinic receptors______________?
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A. Terfenadine

B. Diphenydramine

C. Promethazine

D. Pyrilamine

68. Drug efficacy refers to_________________?
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A. The therapeutic index of the drug

B. Range of disease in which the drug beneficial

C. The therapeutic does range of the drug

D. Maximal intensity of response that can be produced by the drug
69. Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of reflex ?
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A. Sodium citrate

B. Ondansetron

C. Metoclopramide

D. Atropine

70. Elimination after 4 half lives in first order kinetics is____________?
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A. 93%

B. 84%

C. 80.50%

D. 4.75%

71. Which of the following is true for carbonic anhydrase inhibitor ?
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A. It causes excertion of Na & Cl

B. It causes metabolic alkalosis

C. It is very potent

D. It is used as an adjunct in epilepsy
72. A factor with a mucopoly saccaride, present in liver, presenting in platelet aggregation is______________?
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A. Prothrombin

B. Acetylsalicylic acid

C. Plasmin

D. Heparin
73. The most common type of epilepsy in children is________________?
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A. Infantile spasm

B. Grand mal epilepsy

C. Petit mal

D. None of the above

74. According to American society of Anesthetists, physical status scale Class III would be_____________?
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A. A normal healthy individual

B. A patient with severe systemic disease that it not in capacitating

C. A patient with mild systemic disease

D. None of the above

75. Idiosyncracy is known as to have_____________?
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A. Genetic component

B. Nutritional component

C. Psychological component

D. Psysiological component

76. The ratio of the median lethal dose of the median effective dose is the_____________?
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A. Morbidity index

B. Therapeutic index

C. Moratality index

D. Anesthetic ratio

77. Which of the following is not an antimigraine agent ?
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A. Flunarizine

B. Propanolol

C. Divalprox sodium

D. Zonisamide
78. Which of the following is a non steroidal anti inflammatory agent with a tendency to produce blood dyscrasias ?
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A. Ibuprofen

B. Aspirin

C. Indomethacin

D. B & C
79. Drug which crosses placental barrier is____________?
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A. All of the above

B. phenytoin

C. Corticosteroids

D. Diazepam

80. Digitalis induced automaticity is enhanced by______________?
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A. Low K+ levels

B. High K+ levels

C. High Na+ levels

D. High Ca2+ levels

81. Which of the following is NOT a systemic effect of corticosteroid ?
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A. Increase in total amount of circulatory neutrophils

B. Increase in IL-1

C. Anti-inflammatory effect is increased

D. Inhibit phospholipase A2

82. Hallucinations are seen after ________ anesthesia?
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A. Thiopentone

B. Ketamine

C. Nitrous oxide

D. Tentanyl

83. A patient on 300 mg of aspirin will show all the following except________________?
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A. Irreversible inhibition of cyclooxygenase path way

B. Inhibition of thromboxane TXA2

C. Prolonged bleeding time

D. Inhibition of prostaglandin PGI2

84. Following drug which undergo most of its metabolism presystemically______________?
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A. Paracetamol

B. Propranolol

C. Verapamil

D. Salbutamol

85. The dose of a drug required to produce a specified effect in 50% of the population is_____________?
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A. Td50

B. Md50

C. Ed50

D. Ld50

86. Km value indicates______________?
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A. Affinity

B. Purity of Enzyme

C. Physiological role

D. Half life enzymes drug complex
87. Which of the following statements regarding nitroglycerin is true ?
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A. Poorly suited for oral administration

B. High membrane penetrability

C. All of the above

D. The effect is more pronounced in venous

88. About heparin true is_____________?
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A. Decrease action of prothrombin III

B. Half-life is 90 min

C. Known to cause idiopathic thrombocytosis

D. Mixture of sulphated polypeptide

89. Sildenafil is inhibitor of_______________?
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A. PDE-5

B. cAMP

C. cGMP

D. PGI2

90. Mandibular sublaxation is associated with________________?
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A. Ciprofloxacin

B. Prochlorperazine

C. Diphenhydramine

D. Carbamezapine

91. Gastric secretion has been shown to be most effectively reduced with the use of___________?
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A. Adrenal steroids

B. H1 histamine receptor antagonist

C. Anticholinergic

D. H2 histamine receptor antagonist
92. Adrenaline can be given in all of the following situations except_______________?
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A. Shock

B. Myocardial infarction

C. Anaphylaxis

D. Asthma

93. When a drug creates an effect that is unpredictable and unique it is termed as____________?
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A. Idiosyncratic effect

B. Toxicity effect

C. Drug on Drug effect

D. Side effect

94. Nitrous oxide is carried in the blood stream by_____________?
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A. Red Blood cells

B. White blood cells

C. Serum

D. Haemoglobin

95. Drugs showing zero order kinetics of elimination_____________?
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A. Are more common than first order kinetics

B. Show a plot of drug concentration versus time that is linear

C. Have a half life independent of dose

D. Decrease in concentration exponentially with time

96. Rapid onset of inhalational GA depends on____________?
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A. All of the above

B. Cerebral blood flow

C. Partial pressure of GA

D. Blood solubility

97. Loading dose depends on_____________?
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A. Volume of distribution

B. Half life

C. Clearance

D. Rate of administration

98. All of the following are tocolytic except_______________?
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A. Atosiban

B. Ritodrine

C. Natrexam

D. Isoxsuprine

99. Which of the following is not a contraindication in the therapy with opioids_____________?
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A. Use in severe constant pain

B. Use in head injury patient

C. Use of agonist with mixed agonist-antagonist

D. use in impaired pulmonary function

100. Drug injury may be caused by therapeutic drugs or______________?
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A. Carcinogens

B. Nontherapeutic agents

C. All of the above

D. Allergens