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pathology MCQs

Practise focused pathology questions with marked answers for exam preparation and subject revision.

pathology Mcqs
1. Which of the following is correct ?
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A. All of the above

B. Pyknosis shrinkage of nucleus

C. Karyolysis Dissolution of nucleus

D. Karyorrhexis fragmentation of nucleus

2. Which of the following statement is _____________?
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A. High density lipoproteins have protective role in atherosclerosis

B. Poly unsaturated fats lowers plasma cholesterol levels

C. Low density lipoproteins has maximum association with atherosclerosis

D. HDL contains the highest cholesterol content
3. Granuloma is characterized by all of the following except______________?
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A. A reaction of acute inflammation

B. A specific type of chronic inflammation

C. Initiated by a number of infectious and non infectious agents

D. Accumulation of modified macrophages

4. Pale infarcts are seen in all of the following except______________?
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A. Spleen

B. Lung

C. Liver

D. Kidney

5. The most common site of metastases of osteosarcoma is_____________?
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A. Spleen

B. Lymph nodes

C. Lung

D. Liver

6. The most common site of origin for venous thrombi leading to pulmonary embolism is_____________?
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A. Deep leg veins

B. Portal vein

C. Ascending oaorta

D. Right atrium

7. The predominant cells after 48 hours of inflammation are_____________?
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A. A and B

B. Neutrophils

C. Macrophage

D. Monocytes

8. Virchow Lepra cells are seen in___________?
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A. lepromatous leprosy

B. Ideterminate leprosy

C. Tuberculoid leprosy

D. Borderline tuberculoid leprosy

9. IN fanconi anemia there is a_______________?
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A. No increased risk of Sq. cell carcinoma

B. Deficiency of copper

C. Mutation of DNA repair gene

D. Purely nutritional disorder etiology

10. Synthesis of DNA occurs in Which phase of cellAcycle________________?
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A. Synthesis S phase

B. Gap G2 phase

C. Mitosis M phase

D. Gap G1 phase

11. Enzymes responsible for suppuration are derived chiefly from_____________?
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A. Monocytes

B. Lymphocytes

C. PMNs

D. Eosinophils

12. Ascites seen in alcoholic liver cirrhosis result form______________?
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A. Decreased protein production by liver

B. Due to increased portal hypertension

C. Due to obstruction of bile duct

D. All of the above

13. Regeneration by sprouting of axons takes place in which end of transaction of nerve_____________?
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A. Proximal end

B. Distal end

C. Both A and B

D. None of the above

14. The intramuscular administration of 0.6 mg of atropine sulphate to a 50 kg adult may produce all of the following effects except_____________?
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A. Mydriasis

B. Decreased Sweating

C. Decreased Salivation

D. Bradycardia
15. Ghon complex of the lung usually____________?
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A. Progresses to tuberculous pneumonia

B. Undergoes calcification

C. Undergoes cavitation

D. Progresses to military tuberculosis

16. The antidote for heparin is______________?
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A. Protamine sulphate

B. Potassium sulphate

C. Pryosulphate

D. Penicillinase

17. Earliest lesion in atherosclerosis is_____________?
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A. None of the above

B. Fatty streak

C. Atheroma

D. Fibrous plaque

18. Immune response to tumour is mediated by_______________?
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A. Humoral mechanism

B. Natural killer cells

C. All of the above

D. Cytotoxic T lymphocytes

19. Why fetal cells continue to divide but terminally differentiated adult cells do not divide ?
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A. Absence of CD kinase

B. Proteinase is absent in fetus

C. Phosphatase absent in fetal cells

D. There are many cyclin inhibitors which prevent cell to enter into S phase in adult
20. The cells which do not undergo mitotic divisions___________?
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A. Endotheilial cells

B. Neurons

C. Bone marrow cells

D. Smooth muscle cells

21. A patient with amenorrhea, short stature, less public hair can be in all of the following except___________?
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A. 46 XY

B. 45 X

C. 46 XXY

D. 47 XXY
22. Caissons disease is caused by______________?
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A. Tumour embolism

B. Air or gas embolism

C. Amniotic fluid embolism

D. Hyper coagulability

23. Earliest transient change following tissue injury_____________?
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A. Lymphocytoses

B. Neutropenia

C. Neutrophilia

D. Monocytoses

24. Auto immune hymolytic anemia is seen in_______________?
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A. CLL

B. ALL

C. CML

D. AML

25. Which of the following is most common location of intracranial neurocysticercoses ?
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A. Brain parenchyma

B. Spinal card

C. Basal cisternae

D. Medulla oblongata

26. Lepra cells seen in leprosy are_____________?
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A. Neutrophils

B. Lymphocytes

C. Plasma cells

D. Vacuolated Histocytes
27. IL-1 helps in_____________?
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A. Inhibits the chemotaxis of neutrophils and macrophages

B. Decreases firbroblast and bone resorption activity

C. Inhibits of B-lymphocytes

D. Stimulation of T-lymphocytes
28. Phagocytes kill bacteria through which mechanism_____________?
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A. Chemotaxis

B. Membrane attack complex killing

C. Oxidative and non-oxidative killing

D. Zipper killing

29. Anaplasia is_______________?
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A. Is a characteristic feature of malignancy

B. All of the above

C. Lack of functional differentiation

D. Lack of structural differentiation

30. Incidence of most common malignant tumours in women is_____________?
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A. Breast

B. Cervix

C. Ovary

D. Lung

31. All of the following events are common to primary and secondary wound healing except_____________?
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A. Inflammatory response

B. Wound contraction

C. Formation of blood clot

D. Epithelial changes

32. Left side heart failure results in______________?
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A. Oedema of liver

B. Oedema of spleen

C. Oedema of lungs

D. Oedema of legs

33. Which of the following is not a mediator of inflammation___________?
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A. Myeloperoxidase

B. Interferon

C. TNF

D. Prostaglandins

34. Philadelphia chromosome is consistently found in_______________?
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A. CLL

B. CML

C. All of the above

D. AML

35. In granuloma, epithelial and giant cells are derived from_____________?
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A. Monocyte

B. T cells

C. B cells

D. Plasma cells

36. Following are functions of prostaglandins except__________?
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A. Lower blood pressure

B. Elevates blood pressure

C. Uterine contraction

D. Increase capillary permeability

37. A shift to left indicates an increase in number of______________?
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A. erythrocytes

B. Platelets

C. matures neutrophils

D. immature neutrophils
38. A 20 year male complains of recurrent attacks of sore tthroat since 2 years. The total leukocyte count was 1000/ul. A differential count revealed severe neutropenia. The diagnosis is________________?
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A. Agraulocytosis

B. Subleukemic leukemia

C. Infectious mononucleosis

D. Leukoerythroblastic anemia

39. Onion skin appearance is seen in_______________?
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A. Fibro sarcoma

B. Osteosarcoma

C. Osteoma

D. Ewings sarcoma
40. DiGeorges syndrome is due to___________?
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A. Chromosomal anomaly

B. Inborn error of metabolism

C. Deficiency of complement factor

D. Congenital thymic aplasia
41. An infarct is most frequently is characterized by What type of necrosis ?
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A. Coagulative

B. Fatty

C. Gangrenous

D. Caseous

42. Granulation tissue contains_____________?
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A. B & C

B. Fibroblasts

C. Endothelial cells

D. Giant cells

43. Anasarca means_____________?
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A. Severe generalized swelling

B. Absence of proliferation of vessels following inflammation

C. Presence of pus

D. Abnormal inflammatory process

44. Sickle cell anemia precipitates when______________?
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A. All of the above

B. Increased viscosity of blood

C. There is dehydration

D. Oxygen tension goes down

45. All of the following statements are true regarding cervicofacial actinomycosis, EXCEPT_____________?
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A. Cultures on blood agar often produce a typical molar tooth morphology

B. The discharging pus contains visible sulphur granules

C. There is usually history of trauma such as tooth extraction or a blow to the jaw

D. 110-20% of actinomycosis cases occur in cervicofacial region
46. The most definite feature of a malignant tumour is_____________?
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A. Necrosis

B. Metastasis

C. Haemorrhage

D. Increased mitoses

47. Lipofuschin is an insoluble endogenous pigment, also known as___________?
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A. All of the above

B. Aging pigment

C. Wear and tear pigment

D. Lipochrome

48. Thrombosis due to hypercoagulability is seen in____________?
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A. Severe trauma or burns

B. Women talking oral contraceptives

C. All of the above

D. Cardiac failure

49. Kviems test is diagnostic test for_________________?
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A. Tuberculosis

B. Actinomycosis

C. Diphtheria

D. Sarcoidosis
50. Prothrombin time indicates the integrity of ____________________?
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A. Intrinsic pathway

B. Extrinsic pathway

C. Capillary function

D. All of the above