pathology Mcqs
251. Which of the following is correct statement ?
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A. TNM and AJC systems can be used for staging malignant tumours

B. Staging is the extent of spread of tumour

C. Grading is the degree of macroscopic and microscopic differentiation of tumour

D. All of the above
252. Difference in transudate & exudate is that the former has a______________?
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A. Cloudy appearance

B. Low protein

C. Increased specific gravity

D. High protein

253. Edema is due to_______________?
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A. Decreased albumin conc. in blood

B. Increased osmotic pressure

C. Increased albumin in blood and decreased globin

D. None of the above

254. Metastatic calcifications are seen in______________?
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A. Hypoparathyroidism

B. Vitamin D deficiency

C. All of the above

D. Hypercalcemia
255. Christmas disease is due to deficiency of________________?
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A. Factor VIII

B. Factor X

C. Factor IX

D. Factor V

257. Severe generalized edema is called as_______________?
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A. Myxoedema

B. Anasarca

C. Dependent edema

D. Pitting edema

258. Which of the following is NOT true of dystrophic calcification ?
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A. Tuberculous lesions

B. Atherosclerotic lesions

C. Occurs in damaged tissue

D. Serum calcium levels are high
259. Pallor, spoon shaped nails, atrophic glossitis, with accompanied dysphagia is typical picture of ______________?
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A. Trotters syndrome

B. Vincent stomatitis

C. None of the above

D. Plummer Vinson syndrome
260. In Hodgkins disease the lymphoa cells seen are__________________?
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A. Giant cells

B. Plasma cells

C. Reed-sternberg cells

D. Eosinophilis

262. The activation of caspases is likely to lead to_________________?
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A. G1 to S phase of cell cycle

B. Blood coagulation

C. Apoptotic cell death

D. Mitotic cell division

263. Chicken-wire appearance of enlarged bone marrow spaces is seen in_______________?
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A. Haemophilia A

B. Sickle cell anaemia

C. Beta thalassemia majon

D. Fetal alcohol syndrome

264. Caseation necrosis is suggestive of________________?
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A. Sarcoidosis

B. Leprosy

C. Tuberculosis

D. Midline lethal granuloma

265. Coagulative necrosis is_______________?
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A. Characteristic of focal bacterial infections

B. Characteristic by loss of tissue architecture

C. Characteristic of hypoxic death

D. None of the above

266. Diabetic gangrene is caused by____________?
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A. Vasospasm

B. Peripheral neuritis

C. Atheroslerosis

D. None of the above

267. Hyper segmented neutrophils are seen in_________________?
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A. Iron deficiency anemia

B. Idiopathic thrombocytopenic purpura

C. Megaloblastic anemia

D. Thalassemia

268. Stain used for demonstration of amyloid is______________?
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A. Congo Red

B. Massons toichrome

C. Reticulin

D. Vonkosa

269. Hemophilia is best treated by _____________?
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A. Whole blood

B. cryoprecipitate

C. factor VIII concentrate

D. dried freeze plasma

270. In leucopenia, which cell type is predominantly involved ?
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A. Erythrocytes

B. Eosinophils

C. Granulocytes

D. Monocytes

271. Pyknosis is characterized by_________________?
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A. Nucleus disintegration

B. Nucleolus disintegration

C. Nuclear basophilia

D. Nuclear shrinkage
272. Hemophilics show_________________?
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A. Decreased bleeding time and increased clotting time

B. Increased bleeding time and clotting time

C. Decreased bleeding time and clotting time

D. Normal bleeding time and increased clotting time
273. Thrombocytosis is seen in_______________?
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A. DIsseminated intravascular coagulation

B. Thiazide therapy

C. Haemolytic anaemia

D. Osteopetrosis

274. Tigered effect of heart is seen in_______________?
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A. Hyaline change

B. Atrophy

C. Amy

D. Fatty change
275. Schilling test is performed to find out______________?
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A. Folic acid level

B. Pancreatic enzyme deficiency

C. B12 malabsroption

D. Coronary artery disease

276. Normocytic, Normochromic anemia is seen in______________?
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A. All of the above

B. Hemolytic anemia

C. chronic disease

D. Acute blood loss

277. Cooleys anemia is also called___________________?
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A. Mediterranean anemia

B. Erythroblastic anema

C. All of the above

D. Beta Thalassemia major

278. Bence jones proteins are associated with__________________?
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A. Multiple myeloma

B. Infectious mononucleosis

C. Hodgkins lymphoma

D. Burkitts lymphoma

279. Hemophilia_______________?
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A. Is a congenital disorder

B. Increased clotting time in all patients

C. Nerve blocks can be given safely

D. Affects males and females equally

280. The dominant histologic feature of infarction is__________________?
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A. Chronic inflammation

B. Liquefactive necrosis

C. Scar tissue

D. Coagulative necrosis
281. Lymphatic leukemoid reaction is usually seen in the following EXCEPT________________?
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A. Tuberculosis

B. Lobar pneumonia

C. Pertussis

D. Viral infections

282. Syndrome associated with increased risk of leukemia is_____________?
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A. Plummer Vinson syndrome

B. Sturge weber syndrome

C. Klinefelter syndrome

D. Multiple hamartoma syndrome

284. Amyloidosis is commonly associated with_____________?
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A. Multiple myeloma

B. Periostitis

C. Chronic osteomyelitis

D. Acute osteomyelitis

285. Pernicious anaemia is associated with the deficiency of________________?
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A. Vitamin B6

B. Vitamin B1

C. Vitamin B12

D. Folic acid

286. Amyloid material can be best diagnosed by___________________?
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A. Polarized microscopy

B. Scanning electron miscroscopy

C. X-ray crytallography

D. Electron microscopy

289. In Troisiers sign the lymph nodes involved are_________________?
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A. Left axillary nodes

B. Right supraclavicular nodes

C. Right axillary nodes

D. Left supraclavicular nodes
290. Which of the following is a hemolytic anemia________________?
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A. All of the above

B. Hereditary spherocytosis

C. Sickle cell anemia

D. Thalassemia

291. Apoptosis is_________________?
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A. Single cell necrosis

B. Neoplastic change in the cell

C. Intracytoplasmic accumulation

D. Degenerative change

293. Normal adult haemoglobin contains________________?
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A. One beta chains and two alpha chains

B. Two alpha chains and two beta chains

C. One alpha chains and two beta chains

D. One alpha chain and one beta chain

294. Both beta chains of haemoglobin are abnormal in_________________?
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A. Heterozygous sickle cell trait

B. Homozygous sickle cell anemia

C. Thalassemia major

D. Megaloblastic anemia

295. In sickle cell anemia there is substitution of_________________?
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A. All of the above

B. Phenylalanine for glutamic acid

C. Tyrosine for valine at the 6th position at beta chain

D. Valine for glutamic acid at the sixth position of beta chain
296. Apoptosis is suggestive of_______________?
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A. Coagulative necrosis

B. Epithelial dysplasia

C. Neo angiogenesis

D. Liquefaction degeneration

297. Which of the following is correctly matched_______________?
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A. Caseation yellow fever

B. Gumma infarction

C. Coagulation necrosis Tuberculosis

D. Fat necrosis Pancreatitis
298. A reduction in the total leucocyte count is called_________________?
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A. Leukemia

B. Leucocytosis

C. Leucopenia

D. Leucorrhoea

299. The protein found in the amyloid deposits in senile systemic amyloidosis is_________________?
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A. Transthyretin

B. a2 microglobulin

C. AL protein

D. a-amyloid protein

300. The type of acute myelogenous leukemia associated with a high incidence of disseminated intravascular coagulation in________________?
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A. Acute promyelocytic leukaemia

B. Acute erythroleukaemia

C. Acute megakaryocytic leukaemia

D. Acute myelomonocytic leukaemia