1201. Salicylate administration is contraindicated in pregnancy because_______________?
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A. Causes pulmonary hypertension of newborn

B. Readily croses placental barrier

C. It delay onset of labour

D. All of these
1202. BEnzodiazepines are true in___________________?
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A. After metabolism of other drugs in liver

B. More safe than other sedatives when take in larger amounts

C. All have metabolically active substrates

D. Produce distortion in sleep more than other sedatives

1203. Majority of drugs are transported across the membrane by____________?
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A. Active transport

B. Filtration

C. Passive diffusion

D. Facilitated trasnsport

1205. Aspirin produces all of the following effects except_____________?
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A. Prolonged prothrombin time

B. Frank gastric bleeding

C. Platelet dysfunction

D. Constipation
1206. Intramuscular route is precluded during the medication of________________?
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A. Anti-diabetics

B. Anticoagulants

C. Anti-fibrinolytics

D. Anti-hypertensives

1208. Drugs exhibiting first pass metabolism are all EXCEPT one______________?
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A. Nitroglycerine

B. Morphine

C. Salicylates

D. Propranolol

1209. An antiepileptic drug used in petitmal epilepsy is______________?
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A. Phenobarbitonse

B. Ethosuximide

C. Diazepam

D. Dilantoin sodium

1210. In which of the following condition thalidomide may be used_______________?
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A. Epilepsy

B. Erythema nodosum leprosum

C. Myocardial infarction

D. Wernickes ecephalo pathy

1212. A common side effect associated with all NSAID drugs is_______________?
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A. Xerostomia

B. Constipation

C. Drowsiness

D. Gastric irritation
1213. Which produces dissociative anaesthesia_____________?
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A. Theiopentone sodium

B. Propanidid

C. Ketamine

D. Fentany droperodol

1214. Centrineuraxial (spinaland epidural) anaesthesia is not contraindicated in____________?
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A. Patient on aspirin

B. Raised intracranial pressure

C. Patient on oral anticoagulants

D. Platalets <80,000

1215. Gastric secretion has been shown to be most effectively reduced with the use of___________?
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A. H2 histamine receptor antagonist

B. H1 histamine receptor antagonist

C. Anticholinergic

D. Adrenal steroids

1217. Therapeutic uses of calcium salts include the following except_________________?
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A. Extreme hyper-Kalemia

B. Osteoporosis

C. Laryngospasm

D. Disorders of coagulation
1218. The organ most resistant to GA is______________?
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A. Cerebrum

B. Medulla oblonagata

C. Spinal Cord

D. Medullary cortex

1220. IV ultrashort acting barbiturate_____________?
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A. Meprobamate

B. Phenobarbitone

C. Thiopentone

D. Pentobarbitone

1221. Aspirin acts on which part of brain ?
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A. Cortex

B. Limbic system

C. Substantia gelatinosa

D. Medulla

1222. The drug not belonging to amide group_______________?
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A. Procaine

B. Bupivacaine

C. Xylocaine

D. Lignocaine

1224. Not true about penicillin G is______________?
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A. Destroyed by gastric acid

B. More concentrated in prostatic secretions and intraocular fluids

C. Very active against sensitive gram positive cocci

D. Used for treatment of meningococcal meningitis

1227. Less gastrointestinal bleed is seen in the following NSAID_______________?
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A. Ibuprofen

B. C0X2 specific inhibitors

C. Naproxen

D. Meloxicam

1229. Drugs that does not cross Blood Brain Barrier______________?
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A. Atropine

B. Physostigmine

C. Scopolamine

D. Neostigmine
1230. Which drugs had high first pass effect_____________?
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A. Disorpyamide

B. Verapamil

C. Phenytoin

D. Amiodarone

1231. Which of the following is true for carbonic anhydrase inhibitor ?
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A. It causes excertion of Na & Cl

B. It is very potent

C. It causes metabolic alkalosis

D. It is used as an adjunct in epilepsy
1232. All are symptoms of opiate withdrawls except______________?
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A. Diarrhea

B. Excessive speech

C. Mydriasis

D. Lacrimation

1233. Which of the following drugs cannot reduce the salivary secretions ?
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A. Disopyrmide

B. Atenolol

C. Neostigmine

D. Amitriptyline

1234. Side of action of muscle selanant is______________?
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A. Myoneural junction

B. Central

C. Ascending reticular

D. Red nucleus activating system

1235. Therapeutic index is____________?
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A. ED50/LD50

B. ED 100/LD 100

C. LD 100/Ed100

D. LD 50/ED500
1237. Action of tannic acid is_______________?
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A. All of the following

B. Astrigent

C. Styptic

D. Blood coagulant

1238. Which drug may be administered even when the patient is on alcoholic beverages ?
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A. Animal charcoal

B. Cefixime

C. Chloral hydrate

D. Glibenclamide

1241. Which drug is present in ledermix paste ?
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A. Demeclocyline

B. Doxycycline

C. Minocycline

D. Tetracycline

1242. Drug which crosses placental barrier is____________?
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A. Diazepam

B. phenytoin

C. Corticosteroids

D. All of the above
1243. Patients tend to exhibit a greater than normal response drugs in each of the following conditions except_______________?
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A. Hepartic cirrhossis

B. Hyperthyroidism

C. Congestive cardiac failure

D. Hypolbuminaemia

1244. Hallucinations are seen after ________ anesthesia?
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A. Tentanyl

B. Ketamine

C. Thiopentone

D. Nitrous oxide

1245. H antagonists are effective in the therapy of all the following except______________?
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A. Parkinsonism

B. Motion sickness

C. Common cold

D. Systemic anaphylaxis

1246. Toxic optic neuropathy can be caused by all of the following EXCEPT_______________?
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A. Ethambutol

B. Ciprofloxacin

C. Tetracycline

D. Ethylene glycol

1247. Loading dose depends on_____________?
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A. Volume of distribution

B. Half life

C. Clearance

D. Rate of administration

1248. B-lactam antibiotics are_____________?
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A. Penicillin

B. Cephalosporins

C. Imipenem

D. All of the above
1249. Agent used in oral thrush_____________?
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A. Miconazole

B. Clotrimazole

C. Clobetasol

D. Amoxycillin