biochemistry Mcqs
51. Galactosemia commonly is due to deficiency of_____________?
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A. Glucose 1 phosphatase

B. Galactose 1 phosphatase uridyl transferase

C. Glucose 6 phosphatase

D. Galactose 1 phosphatase

52. Which of the following is correctly matched ?
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A. Malate to oxaloacetate -1 ATP is formed

B. Succinate to furmarate -1 ATP is formed

C. Isocitrate to oxalo succinate -1 ATP is formed

D. Succinyl CoA to succinate -1 ATP is formed
53. Which of the following is not a product of HMP shunt_____________?
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A. NADPH

B. D sedoheptulose 5 phosphate

C. D glyceraldehyde 3 phosphate

D. D fructose 6 phosphate

54. Most importent compansatory mechanism in metabolic acidosis______________?
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A. Increased urinary phosphates

B. Increased NH3 excretion by kidneys

C. Hyperventilation

D. Increased HCO3 Production

55. Hexokinase is a______________?
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A. Reductase

B. Oxidase

C. Oxidoreductase

D. Transferase
56. Which of these organelle functions as the digestive system of the cell ?
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A. Mitochondria

B. Lysomes

C. Rough endoplasmic reticulum

D. Golgi apparatus

57. Bile acids are formed from__________?
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A. Lipoproteins

B. Bilirubin

C. Aminoacids

D. Cholesterol
58. The most common enzyme deficiency in man is___________?
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A. Glucose 6 phosphate dehydrogenase

B. Hexokinase

C. Glucose 1,6 diphosphatase

D. Glucose 6 phosphatase

59. Enzyme that catalyses the transfer of a molecule group from one molecule to another is_____________?
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A. LIpases

B. Oxidases

C. Transferases

D. Peptidases

60. Step in HMP pathway requiring TPP_____________?
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A. G6 PD

B. 6 phosphogluconate dehydrogenase

C. Transaldolase

D. Transketolase
61. Increase in pyruvate and lactate is seen in which of the following deficiency ?
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A. Vitamin C

B. Thiamine

C. Pyridoxine

D. Niacin

62. Enzymes are classified according to_________________?
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A. Nature of the enzymes

B. Action on substrate

C. Action of coenzymes

D. All of the above

63. Gluconeogenesis occurs in the liver and _______?
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A. Fat

B. Heart

C. Muscle

D. Kidney
64. McArdles disease is due to the deficiency of_____________?
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A. Myophosphorylase

B. Glucose 6 phosphatase

C. Glucose 1 phosphatase

D. Glucose 1,6 phosphatase

65. Krebs cycle occurs in _________ conditions?
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A. Anaerobic

B. Microaerophilic

C. Aerobic

D. Aerobic and anaerobic

66. In mycocarrdial infarction the first enzyme to rise____________?
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A. SGOT

B. CPK

C. Amylase

D. LDH

67. To keep blood PH at 7.4 the HCO3 : H2CO3 ratio should be_____________?
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A. 15:01

B. 30:01:00

C. 1:01

D. 20 : 1
68. All these reactions take place inside the mitochondria except____________?
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A. EMP pathway

B. Urea cycle

C. Krebs cylce

D. Electron transfer

69. Iron is present in all of the following except_______________?
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A. Catalase

B. Myoglobin

C. Pyruvate kinase

D. Cytochrome

70. An example of layses is_____________?
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A. Amylase

B. Glutamine synthetase

C. Fumarase

D. Cholinesterase

71. The tissue with the highest glycogen content (mg/100gm)_____________?
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A. Muscle

B. Kidneys

C. Liver

D. Testes

72. Which acid is formed in the citric acid cycle ?
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A. Oxaloacetic acid

B. None of the above

C. Glutamic acid

D. Nitric acid

73. Which one of the following enzymes provides a link between glycolysis and the citric acid cycle ?
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A. Pyruvate dehydrogenase

B. Lactate dehydrogenase

C. Citrate synthase

D. Pyruvate kinase

74. Renal threshold for glucose is______________?
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A. 200 mg%

B. 180 mg/ dl

C. 100 mg%

D. 80 mg%

75. Insulin acts on which enzyme in glycolysis ?
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A. Glucose 6 phosphatase

B. Adenylate kinase

C. Glucokinase

D. Hexokinase

76. Most lipogenic____________?
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A. Glucose

B. Galactose

C. Ribose

D. Fructose
77. When the prosthetic group of an enzyme is an inorganic ion, it is called a_____________?
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A. Apoenzyme

B. Coenzyme

C. Cofactor

D. Holoenzyme

78. Number of ATP molecules generated in the conversion of glycogen of lactate is_____________?
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A. 2

B. 38

C. 36

D. 32

79. Fraction of CPK is an enzyme that is elevated in a myocardial infarct is____________________?
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A. MM fraction

B. MB fraction

C. BB fraction

D. Both MM and BB fraction

80. During phagocytosis the metabolic process called respiratory burst involves activation of_____________?
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A. Hydrolase

B. Dehydrogenase

C. Peroxidase

D. Oxidase
81. Dietary fibre is rich in_____________?
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A. Starch

B. Collagen

C. Inulin

D. Cellulose
82. Enzymes concerned with the citric acid cycle are found in the____________?
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A. Mitochondria

B. Ribosomes

C. Nonparticulate cytoplasm

D. Nucleus

83. In TCA cycle substrate level phosphorylation occurs at____________?
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A. None of the above

B. Thiokinase

C. Succinate dehydrogenase

D. Malonate reduction

84. The key enzyme of gluconeogenesis is______________?
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A. Phosphoenol pyruvate carboxykinase

B. Glucose 6 phosphatase

C. Pyruvate carboxylase

D. Fructose 1,6 disphosphatase

85. Which one of the following is a monosaccharide______________?
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A. Strach

B. Sucrose

C. Maltose

D. Fructose
86. In prolonged starvation the main nergy source of brain is_____________?
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A. Fatty acids

B. Ketone bodies

C. Fructose

D. Glucose

87. Which of the following is correct of the pyruvate dehydrogenase enzyme complex ?
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A. It is present in cytoplasm

B. Catalyzes the conversion of pyruvate to oxaloacetate

C. Catalyzes a reversible reaction

D. Requires TPP as cofactor
88. Enzymes help by____________?
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A. Decreasing the surface tension

B. Lowering the activation energy

C. Increasing the substrate concentration

D. Increasing the activation energy

89. An enzyme that makes a double stranded DNA copy from a single stranded RNA template molecule is known as____________?
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A. Phospho kinase

B. RNA polymerase

C. DNA polymerase

D. Reverse transcriptase
90. Nor epinephrine is converted to epinephrine by______________?
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A. Dopa decarboxylase

B. O-methylation

C. Dopamine hydroxylase

D. N-methylation
91. The amino acid required for the synthesis of haem is______________?
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A. Glycine

B. Lysine

C. Glutamic acid

D. Glutamine

92. Golgi bodies function are______________?
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A. Protein synthesis

B. None of the above

C. Sorting of glycoproteins

D. Protein lipid synthesis

93. One of the earliest symptoms of Vit. A deficiency is________________?
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A. Bitots spot

B. Keratomalacia

C. Nyctalopia

D. Xerophthalmia

94. Dehydrogenase used as coenzymes all of the following, except________________?
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A. NADP+

B. FMN

C. FAD

D. Ferro protoporphyrin
95. Km of an enzyme is_____________?
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A. Numerically identical for all isozymes that catalyses a given reaction

B. Substrate concentration at half maximal velocity

C. Dissociation constant

D. The normal physiological substrate concentration

96. Michaelis-Menten hypothesis states that_____________?
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A. Rate of enzymatic reaction is independent of substrate concentration

B. Enzyme- substrate complex formation is essential in enzymatic reaction

C. Rate of non enzymatic reaction is proportional to substrate concentration

D. Km is the enzyme substrate complex association constant

97. Which cell organelle contains DNA_____________?
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A. Mitochondrion

B. Centriole

C. Golgi body

D. Endoplasmic reticulum

98. Megnesium is needed for the activity of which enzymes ?
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A. Dismutase

B. ATPase

C. Aldolase

D. Phosphatase

99. The enzyme involved in the first committed step of glycolysis is____________?
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A. Glucose-6-Phosphatase

B. Phosphofructokinase

C. Enolase

D. Hexokinase
100. Which of the following is not a polymer of glucose?
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A. Amylase

B. Glycogen

C. Inulin

D. Cellulose