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biochemistry MCQs

Practise focused biochemistry questions with marked answers for exam preparation and subject revision.

biochemistry Mcqs
1. Which of the following has a ketogenic effect on livers______________?
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A. Androgen

B. Glucagon

C. Insulin

D. GH

2. Which one of the following human tissues contains the greatest amount of body glycogen ?
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A. Kidney

B. Liver

C. Skeletal muscle

D. Cardiac muscle

3. Inhibition of glycolysis by O2 is known a_____________?
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A. Gluconeogenesis

B. Pasteur effect

C. Hill reaction

D. Muni effect

4. A example of a preventive antioxidant is_______________?
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A. Catalase

B. Superoxide dismutase

C. Tocopherol

D. Urate

5. The main enzyme responsible for activation of xenobiotics in (detoxification)____________?
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A. Cytochrome P-450

B. NADPH cytochrome P-450 reductase

C. Glucuronyl transferase

D. Glutathione S-transferase

6. In TCA, substrate level phospherylation takes place in______________?
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A. Alpha ketoglutrate to succinyl CoA

B. Oxalocetate to citrate

C. Succinate to fumarate

D. Succinyl CoA to Succinate
7. The conversion of glucose 6-P to fructose 6-P is an example of which of the following reactions___________?
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A. Dehydration

B. Aldol cleavage

C. Phosphate transfer

D. Isomerisation
8. Fructose intolerance is to_____________?
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A. Fructose and sucrose

B. Fructose and glucose

C. Fructose only

D. Sucrose only

9. Sites where HMP shunts can occur include_______________?
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A. Lactating mammary gland

B. Liver

C. All of the above

D. WBC

E. Testes

10. Enzymes stored in muscle is________________?
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A. SGPT

B. Alkaline phosphatase

C. CPK

D. SGOT

11. The activity of this plasma enzyme is responsible virtually for all plasma cholesterol esters in humans_______________?
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A. Phospho mevalonate kinase

B. HMG CoA reductase

C. Lecithin cholesterol acyl transferase (LCAT)

D. Pyrophospho mevalonate decarboxylase

12. One molecule of acetyl Co-A gives rise to ________ ATP molecules?
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A. 32

B. 8

C. 12

D. 2

13. The enzyme phosphofructo kinase-1 is strongly activated by_______________?
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A. Fructose 2,6 bis phosphate

B. Citrate

C. Adenosine tri phosphate

D. Cyclic AMP

14. The enzymes that catalyses the same reaction but differ in physical properties are called as_____________?
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A. Pro enzyme

B. Co-enzyme

C. Iso enzyme

D. Holoenzyme

15. A relatively component of the electron transporting respiratory chain is_____________?
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A. Flavoprotein

B. Cytochrome A

C. Ubiquinone

D. Cytochrome Cl

16. Ubiqultin is involved in_____________?
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A. Intracellular proteolysis

B. Electron transport chain

C. Transport of ATP

D. Protein folding

17. Oligosaccharide is________________?
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A. Dextrin

B. Maltose

C. Gructose

D. Glucose

18. Competitive enzyme inhibition will cause_____________?
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A. Decrease of km and increase of Vmax

B. Decrease of km and decrease of Vmax

C. Increase of km and Unchanged of Vmax

D. increase of km and increase of Vmax

19. The end product of glycolysis under anaerobic conditions is_______________?
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A. Pyruvic acid

B. Acetoacetic acid

C. Oxaloacetic acid

D. Lactic acid
20. All of the following are substrates for gluconeogenesis except_______________?
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A. Oleic acid

B. Alanine

C. Glycerol

D. Tryptophan

21. Which metabolite of TCA cycle is used in detoxification of ammonia in brain_____________?
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A. Glycine

B. Alpha ketoglutarate

C. Ornithine

D. Oxalocetate

22. Coenzyme responsible for single carbon transfer is______________?
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A. Acetyl co enzyme A

B. THF4

C. Pyridoxine

D. Biotin

23. Which of the following statement is TRUE? The hydrolysis of lactose yields glucose and galactose_____________?
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A. The hydrolysis of lactose yields glucose and galactose

B. The hydrolysis of sucrose yields only glucose

C. The hydrolysis of maltose yields glucose and fructose

D. All of the above statements are true

24. During conversion of glycerol to pyruvic acid, the first glycolytic intermediate to form is_______________?
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A. 2- phospho glyceric acid

B. Dihydroxy acetone phosphate

C. 3- phospho glyceric acid

D. 3- phospho glyceralehyde

25. Krebs cycle does not occur in______________?
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A. RBC

B. All of the above

C. Muscle

D. Heart

26. Glucose 6 phosphatase deficiency is seen in______________?
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A. McArdles syndrome

B. Downs syndrome

C. Von Gierkes disease

D. Pompers disease

27. Enzymes concerned with the citric acid cycle are found in______________?
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A. Nucleus

B. Non-particulate cytoplasm

C. Mitochondria

D. Ribosomes

28. Bile contains______________?
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A. All of the above

B. Lithocholic acid

C. Deoxycholic acid

D. Chenodeoxycholic acid

E. Cholic acid

29. Muscle glycogen, which cannot contribute to blood glucose due to the absence of which enzymes ?
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A. Phosphoglutamase

B. Debranching enzyme

C. Branching enzyme

D. Glucose-6-phosphotase
30. Which of the following is abnormal constituent of urine_____________?
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A. Urea

B. glucose

C. Creatine

D. None of the above

31. Serum alkaline phosphatase level increase in_______________?
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A. Hypothyroidism

B. Carcinoma of prostate

C. Hyperparathyroidism

D. Myocardial infarction

32. Synthesis of protein occurs on_____________?
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A. Mitochondria

B. Poly ribosomes

C. Golgi bodies

D. Nucleus

33. Multiienzyme complex in human_______________?
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A. Fatty acid synthetase

B. Malonyl CoA carboxylase

C. Carbomoyl Phosphate synthetase

D. Adenosine phospho ribosyl transferase

34. Glucose can be synthesized from all except_____________?
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A. Glycerol

B. Acetoacetate

C. Lactic acid

D. Amino acids

35. Which is not a oligosaccharide sugar ?
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A. Sucrose

B. Maltose

C. Lactose

D. Galactose
36. An essential for the conversion of glucose to glycogen in liver is____________?
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A. GTP

B. Guanosine

C. UTP

D. Pyruvate Kinase

37. Inactive precursors of enzymes are known as_______________?
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A. Coenzymes

B. Proenzymes

C. Holoenzymes

D. Apoenzymes

38. Glycogen breakdown leads to formation of______________?
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A. Lactic acid

B. Glucose & Lactic acid

C. Glycoprotein

D. Glucose

39. An enzyme not involved in glycolysis is______________?
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A. Phosphoglycero mutase

B. Aldolase

C. Glycerophosphate dehydrogenase

D. Enolase

40. Which of them is multienzyme complex_____________?
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A. Pyruvate dehydrogenase

B. Alpha ketoglutarate dehydrogenase

C. Succinate dehydrogenase

D. Enolase

E. Both A & B
41. In TCA cycle, citrate is converted in to after losing a molecule of H2O_____________?
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A. Glutarate

B. Isocitrate

C. Cisaconitate

D. Oxalocetate

42. The enzyme that is specifically increased in obstructive jaundice is_____________?
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A. Glutamate oxaloacetate transaminase

B. Alkaline phosphaase

C. Acid phosphatase

D. Glutamate pyruvate transaminase

43. Which of the following is a non-reducing sugar____________?
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A. Lactose

B. Glucose

C. Maltose

D. Sucrose
44. Which one of the following is the correct sequential order in which the given enzymes of krebs cycle are formed after a molecule of acetyl CoA______________?
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A. Citrate, Oxalocetate, Ketoglutarate

B. Citrate, Ketoglutarate, Oxalocetate

C. Oxalocetate, Ketoglutarate, Citrate

D. Ketoglutarate, Oxalocetate, Citrate

45. Which of the following enzymes use NADP as coenzyme ________________?
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A. Lactate dehydrogenase

B. Beta hydroxy acyl CoA dehydrogenase

C. Glyceraldehyde 3 phosphate dehydrogenase

D. Glucose 6-Phosphate dehydrogenase
46. Adrenaline acts on which enzyme in glycogenolysis ?
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A. Glucose diphosphatase

B. Hexokinase

C. Phosphorylase

D. Glucokinase

47. Key glycolytic enzymes_____________?
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A. Phosphofructokinase

B. Glucose 1,6 diphosphatase

C. Pyruvate kinase

D. Hexokinase

48. The rate of absorption of sugars by the small intestine is highest for_______________?
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A. Hexoses

B. Polysaccharides

C. Disaccharides

D. Pentoses

49. The activity of the following enzyme is affected by biotin deficiency____________?
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A. Carboxylase

B. Transketolase

C. Dehydrogenase

D. Oxidase

50. Which of the following is a function of the golgi apparatus ?
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A. Modification of proteins

B. m RNA synthesis

C. Protein storage

D. t RNA synthesis