1101. In which of the following stage general anesthesia surgery is done_______________?
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A. Stage I

B. Stage III plane 3

C. Stage III plane 2

D. Stage II

1102. Clotting time is most like to be prolonged by the administration of____________?
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A. Barbiturates

B. Acetyl salicylic acid

C. Vitamin K

D. Acetominophen

1103. Which of the following opioids is not given intrathecally ?
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A. Remifentanil

B. Fentanyl

C. Morphine

D. Sufentanil

1104. Prolonged use of aspirin leads to______________?
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A. Bleeding defects

B. Carcinoma

C. A & B

D. peptic ulcer

1106. The principle central action of caffeine is on the________________?
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A. Hypothalamus

B. Corpus callosum

C. Spinal cord

D. Cerebral cortex
1107. Carbamazepine is a type of___________?
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A. Antinflammatory

B. Antiemetic

C. Antibiotic

D. Antidepressant
1108. Rapid onset of inhalational GA depends on____________?
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A. Partial pressure of GA

B. All of the above

C. Cerebral blood flow

D. Blood solubility

1109. Drug efficacy refers to_________________?
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A. The therapeutic does range of the drug

B. Range of disease in which the drug beneficial

C. The therapeutic index of the drug

D. Maximal intensity of response that can be produced by the drug
1110. All of the following are vasodilators except______________?
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A. Procaine

B. Cyclopropane

C. Etomidate

D. Cocaine
1111. Which of the following is not a contraindication in the therapy with opioids_____________?
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A. use in impaired pulmonary function

B. Use of agonist with mixed agonist-antagonist

C. Use in head injury patient

D. Use in severe constant pain
1112. Imatinib acts on______________?
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A. Tyrosin Kinase receptors

B. IL-2 receptors

C. Alpha TNF receptors

D. Inhibits Phosphodiesterase

1113. All are true of diazapenes except____________?
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A. Benzodiazepam is used in the long term treatment of psychic disorders

B. None of the above

C. Clonazeppam is used in the treatment of petitmal epilepsy

D. Benzodiazepam is used in treatment of status epilepticus

1114. Which of the following can cause seizure ?
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A. Tacrolimus

B. Levocetrizine

C. Tramadol

D. Isoniazid
1115. Which of the following is not a Glycoside ?
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A. Digitoxin

B. Ergotoxine

C. Gitoxin

D. Digoxin

1117. Use of morphine is contraindicated in the following conditions except_______________?
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A. Bronchial asthma

B. Acute abdominal pain before diagnosis

C. Head injury

D. Acute myocardial infarcation
1120. Which drug is not acetylated ?
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A. Hydralazine

B. Dapsone

C. Metaclopramide

D. INH

1121. NSAID which undergoes enterohepatic circulation______________?
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A. Phenylbutazone

B. Aspirin

C. Ibuprofen

D. Piroxicam
1123. Which factor of the following contributes to short duration of anesthetic action of single dose thiopental_____________?
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A. Ability to enter and leave brain tissue every rapidly

B. Rapid biotransformation

C. Rapid accumulation in body fat

D. High lipid solubility
1124. Shortest acting opioid analgesic is______________?
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A. Morphine

B. Fentanyl

C. Remifentanil

D. Sufentanil

1125. Neuro adaptation to drug is same as______________?
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A. Psychological dependence

B. Habituation

C. Addiction

D. Physical dependence
1126. Immune mediated qualitative drug intolerance is called______________?
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A. Hyper sensitivity

B. Super sensitivity

C. Hyper acidity

D. Idiosyncrasy

1128. Which one of the following NSAIDs has adverse effects on liver ?
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A. Acetaminophen

B. Aspirin

C. Diclofenac Sodium

D. Ibuprofen

1129. Which is not antiemetic ?
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A. Phenazocine

B. Ondanestron

C. Domperidone

D. Cyclizine

1130. The first choice of drug for patitmal seizure is________________?
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A. Phenobarbitone

B. None of the above

C. Phentoin sodium

D. Carbamazepine

1131. B- blocker with additional a-blocking property is____________?
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A. Labetalol

B. Propranolol

C. Metoprolol

D. Timolol

1132. Which of the following is used in the prophylaxis of migraine ?
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A. Topiramate

B. Phenobarbitone

C. Ethosuxamide

D. Carbamazepine

1133. The following statements about verapamil are true except_____________?
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A. It does not produce reflex tachycardia

B. It is contraindicated in patients with supraventicular tachycardia

C. It can cause constipation

D. It is less potent as a coronary vasodilator

1134. Digitalis induced automaticity is enhanced by______________?
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A. High Ca2+ levels

B. High K+ levels

C. Low K+ levels

D. High Na+ levels

1137. Xerostomia is treated with_____________?
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A. Neostigmine

B. Scopalamine

C. Atropine

D. Ephedrine

1138. The most prominent toxic effect associated with acetominophen use is______________?
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A. Haemorrhage

B. Respiratory alkalosis

C. Hepatic necrosis

D. Gastric Ulceration

1139. A side effect of an antithyroid drug is______________?
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A. Tremors

B. Obesity

C. Hypothyroidism

D. Hypotension

1140. About articaine, all are true except_____________?
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A. More breaks down causes more toxicity

B. Is amide which is metabolized in liver

C. Plasma half-life is 90 min

D. Mandibular infiltration is more effective than nerve block in mandibular molar teeth

1141. The drug Amifostine is used in subjects undergoing radiotherapy for cancer as it________________?
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A. Promotes damage of DNA

B. Prevents repair of damaged DNA

C. Enhances the production of free radicals

D. Scavanges free radicals
1142. Dermatologic manifestation of drug allergy are managed by_____________?
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A. Pirenzepine

B. Chlorpheniramine

C. Ranitidine

D. Lorazepam

1143. Drug not requiring dose adjustment in renal disease is___________?
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A. Calcium channel blocker

B. Vancomycin

C. Metronidazole

D. Aminoglycoside

1145. Drugs like barbiturates precipitate symptoms of prophyria because______________?
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A. They depress ALA synthase

B. They inhibit heme oxygenase

C. They inhibit ALA synthase

D. They induce heme oxygenase

1147. Aspirin is contraindicated in_______________?
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A. Angina

B. Peptic ulcer

C. MI

D. Hypertension

1149. A patient on 300 mg of aspirin will show all the following except________________?
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A. Prolonged bleeding time

B. Inhibition of thromboxane TXA2

C. Inhibition of prostaglandin PGI2

D. Irreversible inhibition of cyclooxygenase path way
1150. Acute Barbiturate poisoning results in_______________?
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A. Liver failure

B. Respiratory failure

C. Convulsions

D. Renal failure