All of the following statements regarding biovailability of a drug are true except______________?

A. It is the proportion (fraction) of unchanged drug that reaches the systemic circulation

B. Low oral biovailability always and necessarily mean poor absorption

C. Biovailability of an orally administered drug can be calculated by comparing the area under cure (o-a) after oral and intravenous (IV) administration

D. Biovailability can be determined from plasma concentration or urinary excretion data

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