pharmacology Mcqs
151. Which of the following anesthetic drugs produces powerful stimulation of the cerebral cortex_____________?
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A. Procaine

B. Lidocaine

C. Tetracaine

D. Cocaine
152. Respiratory depression is seen with_____________?
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A. Antidepressants

B. Tranquilizers

C. Synthetic narcotics

D. Non-barbiturates

153. Imatinib acts on______________?
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A. Inhibits Phosphodiesterase

B. Alpha TNF receptors

C. IL-2 receptors

D. Tyrosin Kinase receptors
154. Ketamine is a________________?
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A. Antidepressive agent

B. Short general anesthetic agent

C. Local anesthetic agent

D. Hypnotic agent

155. B- blocker with additional a-blocking property is____________?
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A. Timolol

B. Propranolol

C. Metoprolol

D. Labetalol
156. In the second stage of anesthesia the pupil is_______________?
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A. Normal in size

B. Totally dilated

C. Constricted

D. Partially dilated
157. The organ most resistant to GA is______________?
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A. Spinal Cord

B. Medulla oblonagata

C. Cerebrum

D. Medullary cortex

158. Neuro adaptation to drug is same as______________?
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A. Habituation

B. Psychological dependence

C. Physical dependence

D. Addiction

159. The drug which has an antabusive effect when alcohol is ingested is______________?
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A. Metronidazole

B. Penicillin G

C. Clindamycin

D. Doxycycline

160. Long acting beta 2 agonist ?
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A. Albuterol

B. Pirlbuterol

C. Orciprenaline

D. Salmeterol
161. Which of the following is an ACE inhibitor ?
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A. Spirino lactone

B. Saralosin

C. Coptopril

D. Diltiazem

162. An antiepileptic drug used in petitmal epilepsy is______________?
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A. Phenobarbitonse

B. Dilantoin sodium

C. Ethosuximide

D. Diazepam

163. Prolonged use of aspirin causes_______________?
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A. Hyprphosphatasia

B. Hypoprothrombinemia

C. Hypercalcemia

D. Hyperprothrombinemia

164. Toxic optic neuropathy can be caused by all of the following EXCEPT_______________?
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A. Ethylene glycol

B. Ethambutol

C. Tetracycline

D. Ciprofloxacin
165. IF patient suffered from exaggerated effect of pharmacological effect____________?
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A. Side effect

B. Idosyncrasy

C. Toxicity

D. None of the above

166. Which of the following cannot be used as a surface local anaesthetics ?
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A. Benzocaine

B. Lidocaine

C. Tetracaine

D. Procaine
167. Which of the following is not a potassium sparing diuretic______________?
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A. Amelioride

B. Triamtrence

C. Spironolactone

D. Bumetainde
168. The statement Not true of Selective Cox 2 inhibitor is________________?
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A. Fewer incidence of gastrointestinal side effect

B. Safe in patients with renal insufficiency

C. The analgesic and anti-inflammatory effects identical to that of Non-selective NSAID

D. They do not offer the cardio protective effect

169. Teratogenicity results when drugs are given during____________?
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A. Soon after birth

B. First trimester

C. Third trimester

D. Second trimester

170. Which of the following is a protective drug in the management of gastric and duodenal ulcers ?
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A. Famotidine

B. NaHCO3

C. Carbenoxolone

D. H2 antihistamines

171. Which of the following is antiasthmatic_____________?
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A. Acetylcholine

B. Serotonin

C. Histamine

D. Salbutamol
172. Each of the following is correct for the treatment of Diarrhoea except_______________?
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A. Kaolin has marginal therapeutic effect

B. Diphenoxylate may cause respiratory depression on administration

C. Opioids delay the passage of gut contents by decreasing peristalsis and increasing intestinal segmentation

D. Loperamide had high abuse potential

173. A patient on digoxin should not be given quindine because______________?
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A. Displaces digoxin from its protein binding sites

B. Decrease the renal clearance of digoxin

C. Decreases the plasma potassium level

D. Displaces digoxine from its tissue binding sites
174. Which one of the following is Not true of angiotensin converting enzyme (ACE) inhibitor____________?
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A. Contraindicated in diabetic nephropathy

B. May cause hyperkalaemia in diabetic patients

C. NSAIDs may impair its hypotensive effect

D. Contraindicated in pregnancy

175. ovidone iodine is the choice of mouthrinse in cases associated AIDS because______________?
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A. It is a topical anesthestic

B. All of the above

C. Its ability to aid in blood coagulation

D. It is a topical antimicrobial
176. Which of the following drug is used to counter act the gastric irritation produced by administration of NSAID_______________?
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A. Betaxolol

B. Misoprostol

C. Pirenzipine

D. Roxatidine

177. Acute Barbiturate poisoning results in_______________?
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A. Liver failure

B. Respiratory failure

C. Renal failure

D. Convulsions

178. Omeprazole is a_____________?
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A. Antihistamine

B. Ulcer protective

C. Proton pump inhibitor

D. Ulcer healing drug

179. The drug which has an affinity for a receptor site and produces the intrinsic activity of the receptor cell or enzyme system is known as____________?
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A. A non competitive antagonist

B. An agonist

C. A competitive antagonist

D. A physiologic antagonist

180. Drug binds to activate the receptor is same fashion, which directly or indirectly brings effect, is_____________?
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A. Antagonist

B. Agonist

C. Partial agonist

D. Inverse agonist

181. A child has phocomelia, this impliments his mother had taken which of the following medication during pregnancy______________?
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A. Chloroquine

B. Thalidomide

C. Tetracycline

D. Warfarin

182. Following inhibits Cytochrome P450_____________?
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A. Ranitidine

B. Famotidine

C. Cimetidine

D. All of the above

183. Therapeutic uses of calcium salts include the following except_________________?
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A. Disorders of coagulation

B. Osteoporosis

C. Extreme hyper-Kalemia

D. Laryngospasm

184. Nitrous oxide is______________?
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A. A good analgesic and a good anesthetic

B. A good analgesic but a poor anesthetic

C. A good anesthetic but a poor analgesic

D. A poor analgesic and a poor anesthetic

185. The most common cause of antibiotic related diarrhea is____________?
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A. C.difficile

B. K.pneumoniae

C. Shigella

D. H.pylori

186. Zero order kinetics is seen with_______________?
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A. Phenytoin

B. Erythromycin

C. Phenabarbtion

D. Digoxin

187. Serum sickness is caused by all the following drugs except_____________?
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A. Sulfonamides

B. Chloroquin

C. Aspirin

D. Pencillins

188. The first choice of drug for patitmal seizure is________________?
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A. Phenobarbitone

B. Phentoin sodium

C. None of the above

D. Carbamazepine

189. Local anaesthetics act by inhibiting_____________?
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A. Only sensory fibres

B. Motor fibers only

C. Motor and sensory fibres

D. None of the above

190. All the following increases drug metabolism by activating cytochrome enzyme, EXCEPT___________?
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A. Phenobarbitone

B. Tetracycline

C. Cimetidine

D. Rifampicin

191. After I.V administration of which of the following anesthetic agent, there is rapid recovery and less headedness ?
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A. Droperidol

B. Midazolam

C. Propofol

D. Diazepam

192. Which of the following drugs cannot reduce the salivary secretions ?
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A. Amitriptyline

B. Disopyrmide

C. Atenolol

D. Neostigmine
193. The following statements about verapamil are true except_____________?
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A. It does not produce reflex tachycardia

B. It is contraindicated in patients with supraventicular tachycardia

C. It is less potent as a coronary vasodilator

D. It can cause constipation

194. The drug not belonging to amide group_______________?
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A. Procaine

B. Bupivacaine

C. Lignocaine

D. Xylocaine

195. For Arsenic poisoning Antidote is_____________?
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A. Penicillamine

B. B.A.L

C. E.D.T.A

D. Desferrixamine

196. Which of the following statements about Azoles is false ?
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A. They are fungistatic

B. They affect the metabolism of drugs such as cyclosporine necessitating an increasing in dosage

C. Resistance to the drug is common

D. They are hepatotoxic

197. All of the following penetrate the CSF except________________?
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A. Diazepam

B. Dopamine

C. Dilantine

D. Dextrose

198. Salbutamol is used in_____________?
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A. Cor pulmonale

B. Cardiac asthma

C. Pulmanray oedema

D. Bronchial asthma
199. One of the obious consequences of alchol ( ethenol), ingestion in many individual is facial flushing and increased heart rate triggered off by alcohol getting metabolized to______________?
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A. Butanaldehyde

B. Acetaldehyde

C. Propanaldehyde

D. Formaldehyde

200. All of the given drugs may be useful in acute exacerbation of bronchial asthma EXCEPT_____________?
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A. Salbutamol

B. Hydrocortisone

C. Cromolyn sodium

D. Ipratropium