1001. Which among the following is Not used for surface anesthesia ?
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A. Tetracaine

B. Lignocaine

C. Procaine

D. Benzocaine

1002. Toxic optic neuropathy can be caused by all of the following EXCEPT____________?
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A. Ethambutol

B. Ethylene glycol

C. Ciprofloxacin

D. Tetracycline

1003. Drug binds to activate the receptor is same fashion, which directly or indirectly brings effect, is_____________?
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A. Inverse agonist

B. Agonist

C. Partial agonist

D. Antagonist

1004. In cirrhoses patients, dose reduction is needed for all the following drugs except_____________?
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A. Lorazepam

B. Metronidazole

C. Paracetamol

D. Theophylline

1005. When given together, the ability of two drugs to produce a response greater than either administered alone is termed as_____________?
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A. Induction

B. Cumulation

C. Antagonism

D. Synergism
1006. After I.V administration of which of the following anesthetic agent, there is rapid recovery and less headedness ?
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A. Propofol

B. Droperidol

C. Midazolam

D. Diazepam

1007. Aspirine cause_____________?
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A. Increase CT

B. Increase PTT

C. Increase BT

D. Increase APTT

1008. A patient has had an allergic reaction with Urticarlia and wheezing. The drug of choice will be_____________?
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A. Epinephrine

B. Hydrocortisone

C. Succinylcholine

D. All of the above

1009. Drug that does not cause sedation________________?
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A. Nitrazepam

B. Diazepam

C. Zopiclone

D. Buspirone
1010. Following analgesic combination should be avoided ?
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A. Ibuprofen and Paracetamol

B. Aspirin and Codeine

C. Ibuprofen and DIclofenac

D. Paracetamol and Dextropropoxyphene

1011. Which of the following second generation anti-histaminics is used topically______________?
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A. Cetrizine

B. Lovocabastine

C. Acrivastine

D. Terfenadine
1012. All the following about antiemetic drugs are correct except_______________?
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A. Ondastran acts on selective 5 -HT3 receptors

B. Ondastran may cause vomiting by effecting the cytotoxic antige receptors

C. Domperidone causes Dystonia

D. Domperidone blocks the D2 receptors in CTZ and upper gut

1013. Which of the following drugs is least efficacious in the treatment of cemporal lobe epilepsy ?
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A. Phenobarbitone

B. Carbamazepine

C. Phenytoin sodium

D. Primidone
1014. Aspirin is avoided in children with influenza infection because of association______________?
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A. Nausea

B. Acid-base imbalance

C. Diarrhoea

D. Reyes syndrome
1015. Km value indicates______________?
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A. Half life enzymes drug complex

B. Purity of Enzyme

C. Physiological role

D. Affinity

1016. Aspirin is used in treatment of Myocardial Infarction___________?
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A. Ithelps in reducing inflammatory aggregate

B. It stimulates Prostacyclins

C. It is a vasodilator

D. It inhibits thromboxanes
1017. Buprenorphine acts by following mechanism________________?
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A. Mu receptor antagonist

B. Kappa receptor partial agonist

C. Mu receptor partial agnoist

D. Kappa receptor antagonist

1018. All NSAIDs block cycloxygenase and____________?
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A. Costaglandin synthesis

B. Preglandin synthesis

C. Prostaglandin synthesis

D. Ectoglandin synthesis

1019. Which of the following anti inflammatory drug is a COX-2 inhibitor_____________?
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A. Sulidec

B. Aspirin

C. Rofecoxib

D. Ketoprofen

1020. According to American society of Anesthetists, physical status scale Class III would be_____________?
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A. A normal healthy individual

B. A patient with severe systemic disease that it not in capacitating

C. A patient with mild systemic disease

D. None of the above

1021. Local anaesthetics act by inhibiting_____________?
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A. Motor fibers only

B. Only sensory fibres

C. Motor and sensory fibres

D. None of the above

1022. Idiosyncracy is known as to have_____________?
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A. Psysiological component

B. Psychological component

C. Nutritional component

D. Genetic component
1023. The drug which has an antabusive effect when alcohol is ingested is______________?
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A. Doxycycline

B. Penicillin G

C. Clindamycin

D. Metronidazole
1024. Drugs used in cysticercosis_______________?
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A. Prazequantal

B. Pyrantel

C. Niclosamide

D. Metronidazole

1025. One of the obious consequences of alchol ( ethenol), ingestion in many individual is facial flushing and increased heart rate triggered off by alcohol getting metabolized to______________?
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A. Acetaldehyde

B. Butanaldehyde

C. Formaldehyde

D. Propanaldehyde

1026. NSAIDs have adverse effect on________________?
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A. Stomach

B. Kidney

C. Bone

D. Liver

1027. The most common cause of antibiotic related diarrhea is____________?
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A. Shigella

B. K.pneumoniae

C. C.difficile

D. H.pylori

1028. Teratogenicity is_______________?
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A. Drug dependence

B. Intolerance to a drug

C. Carcinoma forming tendency

D. Fetal malformation
1029. The antiseptic recommended for application in oral mucosa is_____________?
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A. Mebromine

B. Hydrogen peroxide

C. None of the above

D. Iodine
1030. One of the following is not an antiemetic_____________?
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A. Chlorpromazine

B. Scopolamine

C. Digitoxin

D. Metaclopromide

1031. Nitrous oxide is carried in the blood stream by_____________?
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A. Red Blood cells

B. Haemoglobin

C. White blood cells

D. Serum

1032. Which of the following is not a potassium sparing diuretic______________?
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A. Amelioride

B. Triamtrence

C. Spironolactone

D. Bumetainde
1033. Which of the following drug is given for treating hypertensive crisis_______________?
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A. NIfedipine

B. Isosobide dinitrate

C. Verapamil

D. Digoxin

1034. Platelet aggregation in inhibited by all except_______________?
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A. Salicylates

B. Phenobarbitone

C. Indomenthacin

D. Dypyradimole

1035. During administration of NSAIDs in children, the most important of dose administration is______________?
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A. Age of child

B. Chronicity of pain

C. Weight of the child

D. Nature of the drug

1036. The statement Not true of Selective Cox 2 inhibitor is________________?
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A. The analgesic and anti-inflammatory effects identical to that of Non-selective NSAID

B. They do not offer the cardio protective effect

C. Fewer incidence of gastrointestinal side effect

D. Safe in patients with renal insufficiency
1037. All of the following statements regarding biovailability of a drug are true except______________?
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A. It is the proportion (fraction) of unchanged drug that reaches the systemic circulation

B. Low oral biovailability always and necessarily mean poor absorption

C. Biovailability of an orally administered drug can be calculated by comparing the area under cure (o-a) after oral and intravenous (IV) administration

D. Biovailability can be determined from plasma concentration or urinary excretion data

1038. The phase I reactions of drug metabolism include The following except_____________?
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A. Conjugation

B. Oxidation

C. Hydolysis

D. Reduction

1039. A child is brought with drowsiness, decreased deep tendon reflexes and seizures. On examination the child has a blue line on gums. There is history of constipation. Which will be most appropriate drug that should be used in this child ?
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A. BAL

B. DMSA

C. EDTA

D. Penicillamine

1040. ovidone iodine is the choice of mouthrinse in cases associated AIDS because______________?
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A. All of the above

B. Its ability to aid in blood coagulation

C. It is a topical antimicrobial

D. It is a topical anesthestic

1041. A patient with grandmal epilepsy would likely be under treatment with_______________?
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A. Meprobamate

B. Phenytoin

C. Pentobarbital

D. Trimethadione

1042. Tannic acid is used in the following conditions except_____________?
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A. Bleeding piles

B. Bleeding gums

C. Alkaloidal poisoning

D. Toothache
1043. Morphine a powerful opioid analgesic drug should be avoided in all the following conditions except____________?
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A. Left ventricular failure

B. Constipation

C. A & C

D. Bronchial asthma

1044. Which among the following is a cell cycle specific anti-neoplastic drug ?
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A. Doxorubicin

B. Cyclophosphamide

C. Methotrexate

D. Cisplatin

1045. Which of the following is NOT a systemic effect of corticosteroid ?
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A. Anti-inflammatory effect is increased

B. Increase in total amount of circulatory neutrophils

C. Increase in IL-1

D. Inhibit phospholipase A2

1046. Teratogenicity results when drugs are given during____________?
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A. Soon after birth

B. Third trimester

C. First trimester

D. Second trimester

1047. Narcotic overdose can be antagonized by______________?
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A. Diphenhydramine

B. Naloxane

C. Nalorphine

D. Atropine

1048. A dentist who first used ether as a general antithetic was_____________?
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A. Morton

B. Morrison

C. Murray

D. Martin

1049. A paralyzing dose of succinylcholine initially elicits______________?
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A. Muscle fasciculation

B. CNS stimulation

C. CNS depression

D. Decreased salivation

1050. Mandibular sublaxation is associated with________________?
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A. Diphenhydramine

B. Carbamezapine

C. Ciprofloxacin

D. Prochlorperazine